A comparison of the opsonic effects of pentameric and monomeric forms of isolated normal IgM demonstrated that, although the monomeric form bound to Bacteroides as effectively as the pentameric form and promoted complement deposition to the same extent, it was unable to enhance alternative pathway-dependent opsonization and adherence of Bacteroides to PMN.

When opsonization was performed in two steps with pentameric IgM added either before or after alternative pathway components, a marked enhancement of adherence to PMN was observed only in the former case, suggesting IgM must act prior to complement to be effective.

Electron microscopic studies demonstrated that, when added with complement, pentameric IgM, but not monomeric IgM, stabilized the bacterial capsule to the dehydration in dimethylformamide used for embedding in Lowicryl K4M. A strong correlation was observed between capsular stability and ability to be bound by PMN.

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Volume , Issue 8. Previous Article Next Article. Article Navigation. Research Article September 08 Female but Not Male Mice Deficient in Soluble IgM Are Susceptible to Chemically Induced Glomerular Injury Russell Whelan ; Russell Whelan.

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Liudmila Kulik ; Liudmila Kulik. Felix Poppelaars ; Felix Poppelaars. Cameron Lee ; Cameron Lee. Michael Holers ; V. Michael Holers. Joshua M. Thurman Address correspondence and reprint requests to Dr. Thurman, Division of Nephrology and Hypertension, C, East 19th Avenue, Aurora, CO E-mail address: joshua.

thurman cuanschutz. Received: April 19 Accepted: August 11 Published: September 08 Online ISSN:

IGT is the global leader in gaming. We deliver entertaining and responsible gaming experiences from Gaming Machines and Lotteries to Sports Betting and Digital Natural immunoglobulin M (IgM) antibodies act synergistically with the alternative complement pathway to promote opsonization and adherence of Bacteroides Researchers have been using antibody tests to try to reveal the true spread of the coronavirus in communities and cities. But these latest

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